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KMID : 0861120110150030163
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Korean Journal of Oriental Preventive Medicine
2011 Volume.15 No. 3 p.163 ~ p.178
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Topical Application of Herbal-mixed Extract on back skin suppresses inflammation in Ovalbumin-induced Atopic Dermatitis
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Jo Hee-Chan
Sul Hyun-Cheol
Kim Sun-Rye
Choi Han-Seok
Shin Yong-Cheol
Ko Seong-Gyu
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Abstract
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Objective: This study is conducted to evaluate the efficiency of ethanol extracts of 4 mixed herbs(CP001
or CP002) on mouse model of atopic dermatitis induced by ovalbumin.
Methods: Female BALB/c mice were internally sensitized with ovalbumin(20㎍) plus aluminum hydroxide
hydrate(4㎎) once per week. After 3 weeks, they were dermally challenged with patches containing ovalbumin
(100㎍) plus aluminum hydroxide hydrate(20㎎) every other day for 3 weeks. After induction of atopic
dermatitis, mice back skin were gently rubbed with CP001 or CP002(200㎎/㎖, 100㎕) for two weeks(every 2
days).
Results: In CP001 or CP002 treated group, there was a remarkable reduction in infiltration of eosinophils
on the skin areas and diminution of mast cells and total T cells in blood samples as compared with control
group. Cutaneous expressions of interleukin-13, 17 were also decreased by CP001 or CP002. Moreover,
blood immunoglobulin E level was decreased by drug administration while there was no decrease in OVA
sensitization group.
Conclusion: In summary, our result shows that herbal extracts(CP001 and CP002) could be potential
candidates for the treatment of chronic atopic dermatitis.
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KEYWORD
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atopic dermatitis, inflammation, ovalbumin, mast cells, immunoglobulin E, herbal extract
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